Merck Decision Tree free essay sample

Merck is a global research-driven pharmaceutical company dedicated to putting patients first. Mercks highest priority areas are Alzheimer’s disease, atherosclerosis, cardiovascular disease, diabetes, novel vaccines, obesity, oncology, pain and sleep disorders. In addition, and importantly for licensing, the following other areas remain of high interest for focused investment in new compounds and mechanisms: antibiotics, antifungals, antivirals (HCV and HIV), asthma, COPD, neurodegeneration, ophthalmology, osteoporosis, schizophrenia, and stroke. In RNA Therapeutics they are interested in: siRNA sequence, structure, and modification Novel chemistries for improving resistance to enzymatic degradation Novel chemistries for reducing immunostimulation Enhanced RISC incorporations Long-term chemical stability Improved target specificity siRNA delivery vehicles for systemic administration Novel polymers and lipids for encapsulation Low toxicity and biodegradable Amenable to use of process development and manufacturing platforms Amenable to molecular targeting strategies Long-term storage stability Delivery vehicles that improve endosomal escape Approaches to molecular targeting of siRNA Targeting using antibodies, peptides, or small molecules Specific for disease-relevant cell types Suitable for nanoparticle or liposome delivery Assays for siRNA intracellular functions Assays for siRNA endosomal escape Biochemical assays for strand selection, RISC incorporation, and catalytic efficiency Assays for clinical biodistribution Cell-based assays to measure toll receptor activation Validated siRNA targets Demonstrated reduction in mRNA and protein levels in animals Reductions have expected effect on disease phenotype miRNA Novel chemistries to create antagomirs Demonstrated reduction of miRNA levels in animals, with evidence that reductions have expected effects on mRNA levels and/or disease phenotype Demonstrated delivery of miRNA in animals, with evidence that increases in miRNA have expected effects on mRNA levels and/or disease phenotype RNA manufacturing Advancements in large-scale production of modified siRNA Improved processes for increased quality and efficiency, and reduced COG Novel chemistries Universal linker-based solid support for production of siRNAs Robust LC-MS method for determination of impurity profile of phosphoramidite raw materials and oligonucleotides (siRNAs) Information technology Registration and tracking of information related to complex multicomponent biologics They are not interested in: Plasmid DNA-based methods for RNA therapies Viral delivery methods for RNA therapies Aptamers as therapeutics RNA delivery vehicles that activate the innate immune response or induce immogenicity Nucleic acid chemistries designed to prevent siRNA passenger strand incorporation into RISC Novel siRNA targets lacking in vivo validation data Biological methods to produce siRNA clinical supplies Oncology In this area they are regarding RNAi especially interested in: Tumor-targeted delivery systems for systemic administration of small molecules, RNAi, and microRNA Tools for development of therapeutic microRNA and antagomirs Platform for identification of tumor-specific antibodies, ligands, or peptides and conjugation chemistry for tumor-targeted delivery Please check the online pdf available at the URL given below for additional information. We will write a custom essay sample on Merck Decision Tree or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page You are invited to provide any opportunity at Merck Licensing online or via the feedback-link provided below.